3 Carcinogenicity

The objective genotoxicity assay the methodology of the carcinogenicity and working group was to assess available for predicting and identifying the human carcinogenicity of chemicals that are subject to review and testing under the Toxic Substances Control Act (TSCA), with emphasis on existing chemicals. Specific objectives were to 1) identify existing assays for assessing or predicting the human carcinogenicity of chemicals, 2) indicate which assays are the most reliable for the prediction of human carcinogenicity, and 3) assess the reliability of low cost predictive assays. This mandate included an assessment of genotoxicity assays in the context of their predictive value for carcinogenicity, but did not include an assessment of other health implications of genotoxicity. The objectives are summarized in table 3-1.